WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Natural killer cell mediated cytotoxicity       ID:04650
C=136; O=4; E=0.18; R=22.65; rawP=3.06e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000104689 NA TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 8797 ENSG00000104689
3  ENSG00000108622 NA ICAM2 intercellular adhesion molecule 2 3384 ENSG00000108622
4  ENSG00000131015 NA ULBP2 UL16 binding protein 2 80328 ENSG00000131015


Database:KEGG pathway       Name:Notch signaling pathway       ID:04330
C=47; O=3; E=0.06; R=49.16; rawP=3.23e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128917 NA DLL4 delta-like 4 (Drosophila) 54567 ENSG00000128917
2  ENSG00000198719 NA DLL1 delta-like 1 (Drosophila) 28514 ENSG00000198719
3  ENSG00000100060 NA MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4242 ENSG00000100060


Database:KEGG pathway       Name:Glycosphingolipid biosynthesis - lacto and neolacto series       ID:00601
C=26; O=2; E=0.03; R=59.24; rawP=0.0005; adjP=0.0018
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174951 NA FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2523 ENSG00000174951
2  ENSG00000176597 NA B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 84002 ENSG00000176597


Database:KEGG pathway       Name:Cell adhesion molecules (CAMs)       ID:04514
C=133; O=3; E=0.17; R=17.37; rawP=0.0007; adjP=0.0019
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000149564 NA ESAM endothelial cell adhesion molecule 90952 ENSG00000149564
2  ENSG00000184113 NA CLDN5 claudin 5 7122 ENSG00000184113
3  ENSG00000108622 NA ICAM2 intercellular adhesion molecule 2 3384 ENSG00000108622


Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=2; E=0.11; R=17.70; rawP=0.0058; adjP=0.0091
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000104689 NA TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 8797 ENSG00000104689


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=3; E=0.34; R=8.72; rawP=0.0050; adjP=0.0091
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000104689 NA TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 8797 ENSG00000104689
3  ENSG00000006210 NA CX3CL1 chemokine (C-X3-C motif) ligand 1 6376 ENSG00000006210


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=3; E=0.35; R=8.49; rawP=0.0054; adjP=0.0091
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000127533 NA F2RL3 coagulation factor II (thrombin) receptor-like 3 9002 ENSG00000127533
2  ENSG00000182162 NA P2RY8 purinergic receptor P2Y, G-protein coupled, 8 286530 ENSG00000182162
3  ENSG00000170989 NA S1PR1 sphingosine-1-phosphate receptor 1 1901 ENSG00000170989


Database:KEGG pathway       Name:Leukocyte transendothelial migration       ID:04670
C=116; O=2; E=0.15; R=13.28; rawP=0.0100; adjP=0.0138
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000149564 NA ESAM endothelial cell adhesion molecule 90952 ENSG00000149564
2  ENSG00000184113 NA CLDN5 claudin 5 7122 ENSG00000184113


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=2; E=0.17; R=11.94; rawP=0.0123; adjP=0.0145
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000196411 NA EPHB4 EPH receptor B4 2050 ENSG00000196411
2  ENSG00000168758 NA SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 54910 ENSG00000168758


Database:KEGG pathway       Name:Hepatitis C       ID:05160
C=134; O=2; E=0.17; R=11.49; rawP=0.0132; adjP=0.0145
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000232810 NA TNF tumor necrosis factor 7124 ENSG00000232810
2  ENSG00000184113 NA CLDN5 claudin 5 7122 ENSG00000184113




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).